A Hospital Based Study to Establish the Correlation between Recurrent Wheeze and Vitamin D Deficiency Among Children of Age Group Less than 3 Years in Indian Scenario
Published: February 1, 2016 | DOI: https://doi.org/10.7860/JCDR/2016/.7287
Santosh Prasad, Rishabh Kumar Rana, Ronak Sheth, Anupama V Mauskar
1. Senior Registrar, Department of Pediatrics, Lokmanya Tilak Municipal Medical College and General Hospital Sion Mumbai, Mumbai, Maharasthra, India.
2. Epidemiologist, Department of Community Medicine, Life Member Indian Medical Association, International Epidemiological Association (USA), IAPSM, India.
3. Senior Registrar, Department of Pediatrics, Lokmanya Tilak Municipal Medical College and General Hospital Sion Mumbai, Mumbai, Maharasthra, India.
4. Addtnl Professor, Department of Pediatrics, Lokmanya Tilak Municipal Medical College and General Hospital Sion Mumbai, Mumbai, Maharasthra, India.
Correspondence
Dr. Rishabh Kumar Rana,
S/O Sri N.P Rana
Malviya Marg, Bansilal Chowk Hazaribag-825301, India.
E-mail : bakwasandsony@gmail.com
Introduction: Early childhood wheezing is a heterogeneous condition, which has several phenotypic expressions and a complex relationship with the development of asthma later in life. New studies indicate the prevalence of recurrent wheeze to be associated with Vitamin D deficiency. This has not been explored in Indian settings widely, mandating this exploration.
Aim: To determine the severity of Vitamin D deficiency and its association with recurrent wheeze in children less than 3 years of age.
Materials and Methods: Consecutive type of non-probability sampling was followed for selection of study subjects with a total sample size to be 122 children in the Hospital setting. A pre- formed, pre- tested, structured interview schedule was used to obtain information. Estimation of 25 (OH) Vitamin D was done using ELISA method. Kit used for estimation was DLD Diagnostika GMBH 25(OH) Vitamin D ELISA from Germany. Standard statistical tools were used including Logistic regression analysis, and ROC curve, p value <0.05 was considered to be statistically significant. SPSS software version 17.0 was used.
Results: Each 10ng/ml decrease in Vitamin D level is associated with 7.25% greater odds of wheezing. Our study also suggests, exclusive breast feeding and delaying of complementary feeding beyond 6 months of age are significant predictors of Vitamin D deficiency and have indirect association with increased incidence of wheezing in children.
Conclusion: The study concluded that Vitamin D deficiency is associated with increased risk of recurrent wheezing.
[
FULL TEXT ] | [ PDF]